![]() The presence of rich networks of DC and macrophages in the vascular and supporting tissues of the brain may play an important role in inflammatory and immune-mediated disorders affecting the CNS, including auto-immune demyelinating diseases such as multiple sclerosis. ![]() In addition to the rich networks of DC, dense populations of resident tissue macrophages (ED2 + and ED1 +) were also demonstrated in the dura mater, leptomeninges and to a lesser extent in the choroid plexus. DAMPs induce further neutrophil recruitment (Pittman and Kubes 2013). These putative DC were negative when stained with the anti-resident tissue macrophage monoclonal antibody ED2. This can result in the presentation of auto-antigens and the production of. These sites included the dura mater, leptomeninges, and the choroid plexus. The present study of normal rat tissues using single and double immunohistochemistry reveals for the first time that extensive networks of major histocompatability (MHC) class II +/OX62 + DC are widely distributed in sites which may potentially encounter CNS antigens. Such a situation was thought to partly explain the 'immune privileged' nature of the central nervous system (CNS). Eppihimer MJ, Kubes P: Varying roles of E-selectin and. ![]() Until now it has been assumed DC are largely absent from the brain, meninges, and the choroid plexus within the ventricles. dermatitis in dogs, including allergic dermatitis, auto- immune dermatitis, pyogranulomatous. They play a crucial role in surveillance of peripheral tissues, trapping antigens encountered there, and migrating via the lymphatics to lymphoid organs where they interact with naive T cells thus generating antigen-specific primary immune responses. Dendritic cells (DC) are regarded as the 'sentinels' of the immune system. ![]()
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